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I have heard this can be a side effect but any suggestions of. But due to the medical advantage of this drug it is still prescribed and administered to patients. The Joys Of Prednisone Asthma Humor Prednisone Asthma Unfortunately others have medical conditions that require them to take prednisone twice daily. Prednisone and insomnia . This is more effective but it s more likely to cause side effects including insomnia. Answer prednisone is a powerful anti inflammatory and immune system suppressor that is used for many conditions. We are going to discuss relationship between prednisone and sleep defects associated with this drug so sit tight and read up. If you are taking prednisone and insomnia becomes a problem you can try improving your sleep habits by avoiding exercise before bedtime sleeping in a dark and quiet room and keeping a regular sleep wake cycle among other things. Hi anyone have a cure for the ridiculous insomnia from prednisone. Prednisone is an anti inflamm...